HGGA

Posted By: HGG Advances HGGA: What motivated you to start working on this project?   JL: Numerous studies suggest red blood cell distribution width (RCDW) and mean corpuscular volume (MCV) are associated with known risk factors for hemorrhagic stroke. However, prior to our study, no causal link had been seen between these blood cell traits and... Read More

Posted By: HGG Advances HGGA: What motivated you to start working on this project?   SM: Working with the Vanderbilt University Undiagnosed Diseases Network (UDN) team during my PhD demonstrated the critical need for better approaches to variant interpretation in rare diseases. And even after a candidate gene and variant are identified, I observed that the... Read More

Posted By: HGG Advances HGGA: What motivated you to start working on this project?   EJ: I wanted to obtain further insights into the genetics of the Greenlandic population, as it is a genetically unique and understudied population. Specifically, we sought to look further into a range of cardiometabolic phenotypes. The end goal was to improve... Read More

Posted By: HGG Advances HGGA: What motivated you to start working on this project?   TS: As RNA-seq is now the state-of-the-art method for measuring gene expression, we were motivated to help researchers better design these experiments for eQTL mapping, a common application using RNA-seq data. We found that it’s possible to boost association power by... Read More

Posted By: HGG Advances HGGA: What motivated you to start working on this project?   AB: Clinical manifestations among C. trachomatis patients are highly variable. For example, up to 80% of C. trachomatis genital infections are asymptomatic and if left untreated, can lead to severe clinical outcomes such as pelvic inflammatory disease, ectopic pregnancies, and infertility.... Read More