Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? JA: There are several important motivations for this work. First, breast cancer is a prevalent female cancer, affecting approximately one in eight women in the United States. This means we all know someone affected by breast cancer and have... Read More
Biomedical Research Funding Insufficient in President’s Budget Proposal On April 3, the Trump Administration released the President’s Budget Request (PBR) for FY 2027. The proposal cuts funding for the National Institutes of Health (NIH) by 12.3 percent, the Advanced Research Projects Agency for Health (ARPA-H) by 37%, and the National Science Foundation (NSF) by more... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? KL: We kept running into GWAS loci where the whole “one variant, one gene” story felt incomplete. You’d fine-map to a regulatory region sitting between multiple genes, and everyone would argue about which one was “the” causal gene—but what if that was... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Authors: We came across the study by Valencia et al. that provided the neurodevelopmental disorder (NDD)-associated variants we used in our study. In that paper, it was shown that mutations causing neurodevelopmental disorders were most enriched in the chromatin-remodeling BAF complex,... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? KK: The initial motivation came from discussions with my advisor, Sebastian Zöllner, PhD, on imputing ancient DNA (aDNA) and whether meta-imputation would be the best way to leverage an aDNA reference panel. We are still working on that question, but... Read More