Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? FR: I had previously developed the graph machine learning framework, Speos, which specializes in the prediction of core genes across several traits. The respective paper, however, primarily focused on benchmarking, validation, and prediction accuracy. Although it... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? JT: This project emerged from an empirical problem we were facing in a separate analysis. In that analysis, we wanted to examine the pattern of genetic variation driven by unique ancestry in human populations in order... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? OP: Despite significant advances in our understanding of the genetic basis of complex traits and diseases — and the potential of polygenic scores (PGS) to guide personalized medicine — these tools are still only beginning to enter clinical use. A major... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Jayati Sharma (JS): I have been interested in how our genetics and environment interact to affect our overall physical health for a long time. Given the significant disparities in the health profiles of different minoritized populations in the United States, I... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? MD: This project began as I rotated in the lab of Christopher (Casey) Brown, PhD. Casey was a leader of the Genotype-Tissue Expression (GTEx) consortium, and his graduate student at the time, Brandon Wenz, had generated... Read More