Posted By: HGG Advances HGGA: What motivated you to start working on this project? Authors: Heart failure is common and deadly, but its genetics are hard to nail down because it’s highly polygenic, and many genome-wide association study signals haven’t been translated into actionable biology or treatment ideas. We were motivated by the strong genetic overlap between... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Most genomic research has focused on individuals of European ancestry and has commonly used imputation panels that contain more European haplotypes, leading to poorer accuracy in other ancestries. In addition, standard panels are largely disease-agnostic, whereas ours is built from Alzheimer’s... Read More
Posted By: HGG Advances HGGA: What motivated you to start working on this project? Anne Gregor (AG): I first became interested in FBXO11, when we and others could link variants in this gene to a variable neurodevelopmental disorder (NDD). As not much was known about neuronal functions of the ubiquitin ligase complex protein FBXO11 and... Read More
For Immediate Release: Wednesday, October 21, 2026, 2:00 p.m. U.S. Eastern Time Media Contact: Evelyn Mantegani, +1 240-833-2014, [email protected] Presented By: Jakob Woerner, PhD, University of Pennsylvania Lifestyle questionnaires can capture what people report eating, how often they exercise, or whether they smoke. But blood proteins may offer another window into how those behaviors affect... Read More
Established in 1949, The American Journal of Human Genetics (AJHG) is ASHG’s flagship scientific journal that continues to publish many of the most important findings in human genetics. Topics range from Mendelian disorders and complex traits to epidemiological studies and population genetics, novel tools and technologies for genetic analysis, and advances in medical applications of genetics and... Read More