Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? ST: Previously, we proposed a haplotype-based scan for recent selection and validated the results in real data using known selected loci in European ancestry groups. We aimed to broaden our scope to more ancestry groups that are often underrepresented in human genetics studies. This objective required us to... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? JD: As I began my PhD in statistical genetics, I wanted to start from the ground up. Much of the excitement in our field today centers on precision medicine, which utilizes genetics to refine disease risk prediction, identify novel... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? FR: I had previously developed the graph machine learning framework, Speos, which specializes in the prediction of core genes across several traits. The respective paper, however, primarily focused on benchmarking, validation, and prediction accuracy. Although it... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? JT: This project emerged from an empirical problem we were facing in a separate analysis. In that analysis, we wanted to examine the pattern of genetic variation driven by unique ancestry in human populations in order... Read More
Posted By: The American Journal of Human Genetics, AJHG AJHG: What motivated you to start working on this project? Valerie Arboleda (VA): The most enjoyable projects often emerge from learning new methods and tackling shared problems. In this case, my friend, co-author (Keriann M. Backus, PhD), and lab neighbor had been generating exciting chemoproteomic datasets... Read More