Description
Dr. Noura Abul-Husn and Sabrina Suckiel will discuss healthcare provider experiences returning monogenic, polygenic, and integrated risk results for common chronic conditions in the eMERGE study. Key findings from a cross-sectional survey of study providers involved in result disclosure highlight differences in confidence and perceived complexity across genomic risk types, as well as key considerations and challenges in communicating polygenic and integrated risk scores.
Overview of Presentation
- The electronic MEdical Records and GEnomics (eMERGE) Network aims to assess the impact of delivering a genome-informed risk assessment for 11 common chronic conditions to 25,000 participants
- The present study examined healthcare provider experiences returning monogenic, polygenic, and integrated risk results
- The study highlights differences in provider confidence, perceived complexity, and communication challenges across genomic risk types and conditions
- Key considerations for returning polygenic and integrated risk scores include the need to contextualize the clinical meaning of results and support patient understanding of risk
- Findings from this study can inform the integration of emerging genomic risk applications into routine clinical care
