Posted By: Kylee Spencer, PhD, Assistant Editor, AJHG KS: What prompted you to start working on this project? SR: When discussing the potential clinical utility of polygenic risk scores, a typical question from the audience is, “Why bother testing your genetic risk profile when the role of genetic risk can simply be measured using a... Read More
Posted By: Kylee Spencer, PhD, Assistant Editor, AJHG KS: What motivated you to start working on this project? WW: This project is motivated by our long-term interest in understanding the molecular mechanisms of complex diseases using genetic data. In the past few years, we have witnessed many successes in gaining biological insights by combining molecular... Read More
Posted By: Sara Cullinan, PhD, Deputy Editor, AJHG SC: What motivated you to start working on this project? HT: Finding faults within the DNA sequences and learning their associations with disease has always piqued my interest. Our lab studies the genomic basis of complex hematological syndromes and particularly the pathogenic effect of a genetic variant... Read More
Posted By: Sara Cullinan, PhD, Deputy Editor, AJHG SC: What motivated you to start working on this project? JV: I have worked on HERG potassium channels for >20 years. Initially I just wanted to understand why these channels have such unusual properties compared to other potassium channels. As part of this work, I studied the... Read More
Posted By: Sara Cullinan, PhD, Deputy Editor, AJHG SC: What motivated you to start working on this project? AS: I’ve been interested in wacky bits of the genome for a long time. I actually remember way back in 2004 when as a postdoc with Evan Eichler we first started getting data from early array CGH... Read More