Distribution of clinical data in prostate cancer affected men with early age at onset. D.M. Mandal1, S.L. Halton2, J.E. Bailey-Wilson3, W. Rayford4. 1) Genetics, Louisiana State University Health Sciences Center, New Orleans, LA; 2) Baylor Clinic, Houston, TX; 3) NHGRI/NIH, Baltimore, MD; 4) Department of Preventive Medicine, University of Tennessee, Memphis,TN.
Several risk factors have been identified in prostate cancer, including age, race and family history. In general, incidence rate of prostate cancer in African-American men is twice as high as the Caucasian males. Earlier studies in literature show that African-American men are often diagnosed with advanced stages of prostate cancer and their age-specific PSA is higher than their Caucasian counterparts. We have identified 125 individuals in our prostate cancer study with early age at onset ( 65 years) from Southern Louisiana. There are 60 African-Americans and 65 Caucasians. Family history was verified for all of them and pathological reports were reviewed. Data were analyzed to observe the distribution of age, PSA and Gleason Scores in two races. A significant difference (p = 0.0008) in the age at onset values was observed between African-American (range 38-65 years with median age of 57.5 years) and Caucasian (range 44-65 years with median age of 61 years) males. No statistical significance was observed in PSA and Gleason Score values in two races. In further analyses, data were stratified with respect to sporadic cases and cases with family history of prostate cancer. African-American and Caucasian cases with family history produced a significant difference of p < 0.01 in the age at onset values. This result enables us to observe clinical characteristics of prostate cancer in different races in Louisiana males, which may contribute significantly in prostate cancer screening strategies.