Tumor marker in the serum proteins of Xiphophorus. A.I. Islam. Ophthalmology, MEEI, Harvard Medical School, Boston, MA.
   Xiphophorus serum proteins were investigated for the establishment of tumor marker in human being. Serum proteins of tumor free and tumor bearing Xiphophorus were conducted in 5% native-PAAG (Polyacrylamide Gel Electrophoresis). Serum proteins of tumor free (Xtf) and tumor bearing (Xtb) Xiphophorus were compared. Both of the strains have 48 chromosomes with similar genetic backgrounds. There have revealed polymorphism in the serum proteins of normal (Xtf) and tumor effected (Xtb) animals. Albumin peaks (molecular wt. - 65 kDa) of tumor free species have high peaks and concentration than Xtb. Lipoproteids peaks (molecular wt. - 24-25 kDa) were more or less similar in patterns in both of the strains. Transferrin peaks and globulin spectra were declining in tumor bearing Xiphophorus. Acute Xtb bear low peaks and contents of lipoproteids than the Xtf fish. Globulin and albumin spectra were more distinct in Xtf than tumor bearing offspring. The quantity of albumin patterns changes in relation to the globulin patterns. Globulin peaks were depressed in the normal and more declining in the acute and tumor-bearing melanoma formed baby Xiphophorus. The tumor free species have the up-rising peaks of globulin and transferrin spectra in comparison to Xtb. From the different patterns of serum proteins, different polymorphic structures were revealed in both Xtf and Xtb strains. This could be an ideal marker for human cancer research.