Nodular hidradenocarcinoma: molecular cytogenetic analysis of a sweat gland tumor in a young male. B. Horst¹, S. Volpert², Ch. Lee¹, HJ. Schulze³, J. Atzpodien⁴, J. Tchinda⁵. 1) Department of Pathology, Columbia University Medical Center, New York, NY; 2) Institut für Humangenetik, Universitätsklinikum Münster, Germany; 3) Fachklinik Hornheide, Department of Dermatology, Münster, Germany; 4) Fachklinik Hornheide, Department of Medicine Oncology, Münster, Germany; 5) Brigham and Womens Hospital, Harvard Medical School, Boston, U.S.A.
   Hidradenocarcinomas are among the least common adnexal tumors of uncertain origin. They range from locally recurring, low-grade well differentiated tumors to highly aggressive tumors with potential for local destruction and distant metastasis to lymph nodes, bone and lungs. Data on cytogenetic analysis of these tumors are very limited. Here, we report the case of a 29-year-old man presenting with a nodular hidradenocarcinoma of the toe and filia to the lung. We used array comparative genomic hybridization (aCGH) on paraffin embedded tissue to characterize the tumor. An approximately 39.2 Mb large deletion of the long arm of chromosome 14 was detected as the sole DNA copy number change related to the tumor. The deletion of cell cycle and RNA transcription regulators in this genomic area may have been contributory to tumor formation in this patient. The patient is doing well with no sign of recurrence two years and five months after surgical resection of the primary tumor and lung metastasis.