3rd Place

 

Jacob Mueller

McNary High School

Teacher: Jessica Graham

 

 

RNA splicing does not always cut out the same introns or keep the same exons. If different exons are used to make the mRNA, a different protein will result. Using exons in this way is called alternative RNA splicing or alternative splicing. . .

. . . Alternative splicing also occurs in the Survival of Motor Neuron (SMN1) gene which primarily produces the protein FL-SMN which is used to assemble components that make up the spliceosome (Meister et al. 2001). When the alternatively spliced variant is produced, intron 3 becomes an exon and shortens the protein overall as intron 3 contains a stop codon (Setola et al. 2007). This protein is called axonal SMN (a-SMN) and it appears to stimulate axon outgrowth and cell motility (Locatelli et al. 2012). Unlike the CARD8 isoforms, these isoforms act on completely different cell functions which shows the great variety of proteins that can be created by alternative RNA splicing.