Dynamics Personal Omics Profiles During Periods of Health, Disease, Weight Gain and Loss. M. Snyder1, W. Zhou1, B. Piening1, K. Kukurba1, K. Contrepois1, C. Craig2, R. Chen1, G. Mias1, J. Li-Pook-Than1, S. Mitra1, L. Jiang1, B. Hanson4, B. Leopold4, S. Leopold4, B. Cooper4, L. Liu2, V. Sikora-Wohfield3, A. Butte1,3, H. Tang1, E. Sodergren4, G. Weinstock4, T. McLaughlin2, M. Snyder1 1) Department of Genetics, Stanford University, Stanford, CA; 2) Department of Medicine, Stanford University, Stanford, CA; 3) Department of Pediatrics, Stanford University, Stanford, CA; 4) Jackson Laboratory for Genomic Medicine, Farmington, CT.

   To understand both how omic information can be incorporated into health care and how physiology changes during periods of healthy and stress periods, we have performed integrated Personal Omics Profiling (iPOP), combining genomic, DNA methylome, transcriptome, proteome, cytokine, metabolome, and microbiome (gut, nasal and other) information, in a cohort of 60 individuals during healthy and aberrant periods. The individuals are sampled frequently during times of respiratory illness, and twenty of the subjects have experienced a high caloric diet (and weight gain) for thirty days followed by low caloric diet (and weight loss) for sixty days. Our iPOP analysis of blood, urine and microbiome components revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways across healthy and disease conditions as well as during weight gain and loss. Our study describes the biochemical and omic pathways associated with respiratory and weight gain stresses at a systems-wide level and those pathways that differ and are in common between different times of environmental stress.

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