Page 109 - ASHG 2013 Program Guide

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INVITED AND PLATFORM SESSIONS
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Thursday, October 24
2:00
PM
–4:15
PM
Concurrent Platform (abstract-driven)
Session C (28-36)
SESSION 28 – Low Frequency Variants for Complex Traits
Hall B2, Level 0 (Lower Level), Convention Center
Moderators
:
Benjamin Voight, Univ. of Pennsylvania;
Ines Barroso, Wellcome Trust Sanger Inst.
169
/2:00
Rare variants contributing to age-
related macular degeneration — Results from the
International AMD Genomics Consortium.
W. M. Igl,
for International AMD Genomics Consortium.
170
/2:15
Identification of new rare coding variants
associated with hemoglobin levels and platelet
counts.
P. Livermore Auer, N. Chami, U. Schick, S.
de Denus, C. Carlson, M. Dube, R. D. Jackson, J. D.
Rioux, C. L. Kooperberg, U. Peters, J. C. Tardif, L.
Hsu, A. P. Reiner, G. Lettre.
171
/2:30
Large-scale whole genome sequencing study
for bone mineral density: The UK10K Consortium.
H. Zheng, V. Forgetta, S. Wilson, C. Greenwood, N.
Timpson, N. Soranzo, T. Spector, B. Richards.
172
/2:45
Identification of 6 novel loci associated with
amino acid levels using single-variant and gene-
based tests.
T. M. Teslovich, J. R. Perry, J. R. Huyghe,
A. U. Jackson, A. Stancˇáková, H. M. Stringham, P. S.
Chines, J. M. Romm, H. Ling, I. McMullen, R. Ingersoll,
E. W. Pugh, K. F. Doheny, J. Kuusisto, F. S. Collins, K.
L. Mohlke, M. Laakso, M. Boehnke.
173
/3:00
Exome analysis in 65,653 European
samples identifies novel low-frequency and
common variants for type 2 diabetes.
C.
Fuchsberger, A. Mahajan, J. Flannick, D. Pasko, N.
Grarup, N. Robertson, X. Sim, N. Burtt, A. Morris, on
behalf of GoT2D Consortium.
174
/3:15
Loss of function mutations in
SLC30A8
protect against type 2 diabetes.
J. Flannick, G.
Thorleifsson, N. L. Beer, S. B. R. Jacobs, N. Grarup,
NNF-CBMR Genetics, Go-T2D/T2D-GENES Consortia,
deCODE Genetics, Pfizer-Broad-MGH-Lund T2D Project.
175
/3:30
Whole genome sequencing of 2,850
Central-Northern European type 2 diabetes cases
and controls reveals insights into functional
mechanisms underlying disease pathogenesis.
K.
Gaulton, J. Flannick, C. Fuchsberger, H. M. Kang, N.
Burtt, J. Ferrer, M. Stitzel, M. Kellis, M. McCarthy, D.
Altshuler, M. Boehnke, GoT2D Consortium.
176
/3:45
Exome chip scan of 74,000 subjects of
European descent and 18,000 subjects of African
descent identify novel genes with functional
mutations influencing adiposity traits.
I. B. Borecki,
CHARGE Adiposity Working Group.
177
/4:00
Large duplications are associated with
increased risk of obesity.
J. S. El-Sayed Moustafa,
M. Falchi, R. G. Walters, I. Prokopenko, A. I. F.
Blakemore, L. J. M. Coin, P. Froguel.
Thursday, October 24
2:00
PM
–4:15
PM
Concurrent Platform (abstract-driven)
Session C (28-36)
SESSION 29 – Selection, Demography and Functional
Polymorphism
Grand Ballroom East, Level 3, Convention Center
Moderators
:
Xiaoming Liu, Univ. of Texas Hlth. Sci.
Ctr. at Houston; Adam Siepel, Cornell Univ.
178
/2:00
A role for host-bacteria interactions in
shaping patterns of genetic variation across human
populations.
R. Blekhman, J. K. Goodrich, K. Huang,
Q. Sun, R. Bukowski, J. T. Bell, T. D. Spector, A.
Keinan, R. E. Ley, D. Gevers, A. G. Clark.
179
/2:15
Using ancient genomes to detect positive
selection on the human lineage.
K. Prüfer, M.
Lachmann, C. Theunert, M. Ongyerth, G. Renaud, M.
Dannemann, T. Neandertal Genome Consortium, S.
Pääbo.
180
/2:30
Reference sample guided pooled
sequencing identifies loss-of-function patterns
across human populations.
A. Eran, M. Carneiro,
G. del Angel, E. Banks, R. Poplin, M. Lek, G. van
der Auwera, S. Fisher, S. Gabriel, D. Altshuler, D.
MacArthur, M. Depristo, 1000 Genomes Project
Consortium.
181
/2:45
Patterns of IBD sharing inferred from
whole genome sequences of 962 European
Americans.
C. V. Van Hout, F. Yu, X. Liu, E.
Boerwinkle, A. G. Clark.
182
/3:00
Reconstructing the genetic demography
of the United States.
R. Sebro, N. Laird, N. Risch.
183
/3:15
Assessing functional potential along
the human genome by integrating comparative,
population, and functional genomic data.
I. Gronau,
B. Gulko, L. Arbiza, M. J. Hubisz, A. Siepel.
184
/3:30
Genome-wide analysis of cold adaption
in indigenous Siberian populations.
A. Cardona, T.
Antao, L. Pagani, D. J. Lawson, C. A. Eichstaedt, B.
Yngvadottir, C. Tyler-Smith, M. T. T. Shwe, J. Wee, I.
G. Romero, S. Raj, R. Villems, M. Metspalu, R. Nielsen,
E. Willerslev, B. A. Malyarchuk, M. V. Derenko, T.
Kivisild.
185
/3:45
Genetic variation is a major source
of transcriptional variation in human-induced
pluripotent stem cells.
N. Kumasaka, F. Rouhani, A.
Bradley, L. Vallier, D. Gaffney.
186
/4:00
Using enhancer activity regulatory
motifs to explore evolutionary trajectories and
disease mechanisms.
L. D. Ward, W. Meuleman,
P. Kheradpour, A. Kundaje, M. Kellis, Roadmap
Epigenomics Mapping Consortium.