Page 127 - ASHG 2013 Program Guide

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INVITED AND PLATFORM SESSIONS
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Friday, October 25
2:00
PM
–4:15
PM
Concurrent Platform (abstract-driven)
Session E (54-62)
SESSION 55 – Impact of Bottlenecks and Population
Growth on Rare Variation
Grand Ballroom East, Level 3, Convention Center
Moderators
:
Itsik Pe’er, Columbia Univ.; Shamil
Sunyaev, Brigham and Women’s Hosp.
340
/2:00
The Ashkenazi Jewish genome.
S. Carmi,
E. Kochav, K. Hui, X. Liu, J. Xue, F. Grady, S. Guha, K.
Upadhyay, S. Mukherjee, B. M. Bowen, V. Joseph, A.
Darvasi, K. Offit, L. Ozelius, I. Peter, J. Cho, H. Ostrer,
G. Atzmon, L. Clark, T. Lencz, I. Pe’er.
341
/2:15
Rare variant sharing reveals population
histories.
I. Mathieson, G. McVean.
342
/2:30
High risk population isolate reveals low
frequency variants predisposing to intracranial
aneurysms.
M. I. Kurki, E. I. Gaál, J. Kettunen, T.
Lappalainen, V. Anttila, F. N. G. van ’t Hof, M. von
und zu Fraunberg, H. Lehto, A. Laakso, R. Kivisaari,
T. Koivisto, A. Ronkainen, J. Rinne, L. A. L. Kiemeney,
S. H. Vermeulen, M. Kaunisto, J. G. Eriksson, T.
Lehtimäki, O. T. Raitakari, V. Salomaa, M. Gunel,
E. T. Dermitzakis, Y. M. Ruigrok, G. J. E. Rinkel, M.
Niemelä, J. Hernesniemi, S. Ripatti, P. I. W. de Bakker,
A. Palotie, J. E. Jääskeläinen.
343
/2:45
Rare variant association studies: What
population genetics models teach us about power
and study design.
B. M. Neale, O. Zuk, E. Hechter,
K. Samocha, M. J. Daly, S. Sunyaev, S. Schaffner, E.
Lander.
344
/3:00
Finnish founding bottleneck leads to
excess of damaging loss-of-function variants with
medically relevant associations.
E. T. Lim, P. Würtz,
A. S. Havulinna, P. Palta, T. Tukiainen, Sequencing
Initiative Suomi Project.
345
/3:15
A rare functional variant in
APOC3
is associated with lipid traits and has risen in
frequency in distinct population isolates.
E. Zeggini,
G. Dedoussis, L. Southam, A.-E. Farmaki, G. R. S.
Ritchie, D.-K. Xifara, A. Matchan, K. Hatzikotoulas,
N. W. Rayner, Y. Chen, C. Kiagiadaki, K.
Panoutsopoulou, J. Schwartzentruber, L. Moutsianas,
E. Tsafantakis, C. Tyler-smith, G. McVean, Y. Xue, I.
Tachmazidou, UK10K Consortium.
346
/3:30
The impact of recent human demography
on deleterious mutation load and the genetic
architecture of disease susceptibility.
G. Sella, Y.
Simons, M. C. Turchin, J. K. Pritchard.
347
/3:45
Inferring ancient demography using
whole-genome sequences from multiple
individuals.
M. Steinruecken, J. Kamm, Y. Song.
348
/4:00
Inferring human population history and
gene flow from multiple genome sequences.
S.
Schiffels, R. Durbin.
Friday, October 25
2:00
PM
–4:15
PM
Concurrent Platform (abstract-driven)
Session E (54-62)
SESSION 56 – Haplotypes, Imputation and Interactions
Grand Ballroom West, Level 3, Convention Center
Moderators
:
Josee Dupuis, Boston Univ. Sch. of Publ.
Hlth; Michael Nothnagel, Univ. of Cologne
349
/2:00
A haplotype map derived from whole
genome low-coverage sequencing of over 25,000
individuals.
J. Marchini, on behalf of Haplotype
Consortium.
350
/2:15
Statistical estimation of haplotype
sharing from unphased genotype data.
D. Xifara,
I. Mathieson, I. Tachmazidou, G. Dedoussis, L.
Southam, K. Panoutsopoulou, K. Hatzikotoulas, E.
Zeggini, G. McVean.
351
/2:30
HapFABIA: Identification of very short
segments of identity by descent via biclustering.
S.
Hochreiter, G. Povysil.
352
/2:45
A new method for genotype calling and
phasing for the 1000 Genomes Project leads to
improved downstream imputation accuracy.
O.
Delaneau, A. Menelaou, J. Marchini, 1000 Genomes
Project Consortium.
353
/3:00
Identification of genetic epistasis in
regulation of gene expression via variance
expression quantitative trait loci.
A. Brown, A.
Buil, M. N. Davies, A. Viñuela, T. Lappalainen, H. F.
Zheng, J. B. Richards, K. S. Small, T. D. Spector, E. T.
Dermitzakis, R. Durbin.
354
/3:15
Association and replication of SNP-SNP
interactions for hundreds of gene expression
phenotypes.
A. Fish, W. Bush.
355
/3:30
Gene-gene interaction analysis for next-
generation sequencing.
J. Zhao, Y. Zhu, M. Xiong.
356
/3:45
Capturing the geographic and genetic
components controlling individual genetic
regulation of cardio-metabolic quantitative traits.
Y. Idaghdour, J. P. Goulet, J. C. Grenier, E. Gbeha,
A. Hodgkinson, V. Bruat, T. de Malliard, J. Hussin, E.
Hip-Ki, P. Awadalla.
357
/4:00
Identification of a set of highly constrained
genes from exome sequencing data.
K. E. Samocha,
E. B. Robinson, B. M. Neale, M. J. Daly.