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Friday, October 14
4:15
PM
–6:15
PM
Concurrent Platform Session C (51-60)
SESSION 60 – Ethical, Legal, Social and Policy Issues
Room 510, Level 5, Convention Center
Moderators:
Stephen Lam, Clin. Genetic Services,
Hong Kong; Bartha Knoppers, McGill Univ., Canada
235
/4:15
The ethical, legal and social implications
of the convergence of cell-free fetal DNA with
genomic sequencing.
J. S. King, M. E. Nunes, S. E.
Kelly, L. C. Sayres, M. Allyse, M. K. Cho.
236
/4:30
Ethical approaches to genotype-driven
research recruitment.
L. M. Beskow.
237
/4:45
The attitudes and opinions of genetic
researchers and clinicians towards direct-to-
consumer genetic testing.
P. M. Kaushik, S. M.
O’Neill, M. G. Hayes, C. A. Wicklund.
238
/5:00
Feedback of individual genetic results to
research participants: In favor of a qualified
disclosure policy.
A. L. Bredenoord, N. C. Onland-
Moret, J. J. M. van Delden.
239
/5:15
Using legislation to facilitate disclosure of
relevant genetic information to genetic relatives:
The Australian experience.
M. F. A. Otlowski.
240
/5:30
Legal provisions related to genetic testing:
The German Act on Genetic Testing (GenDG; 2010).
H. Tonnies.
241
/5:45
Science regulation and the complexities of
genomics.
J. M. Siqueiros, A. Arellano, E. Schwartz,
G. Saruwatari, P. F. Oliva.
242
/6:00
Long-term follow-up data collection after
newborn screening: Development of a consensus
core data set.
S. A. Berry, A. M. Brower for Joint
Committee, NICHD-NBSTRN Clin. Ctrs. Workgroup &
HRSA-NCC/RC Long-Term Follow-Up Workgroup.
Cameras and all other recording devices are
strictly prohibited
in all session rooms. Thank you for your cooperation
Saturday, October 15
8:00
AM
–10:00
AM
Concurrent Invited Session IV (61-66)
SESSION 61 – Human Molecular Cytogenetics:
Functional Nuclear Architecture and Disease
Room 517D, Level 5, Convention Center
Moderator:
Thomas Cremer, LMU Biocenter, Germa
This session is devoted to the functional nuclear
organization in space and time, including the structu
and arrangements of chromosome territories (CTs),
active and silent genes, as well as the topography o
machineries for DNA replication, transcription and
repair. In order to understand the generation of cell
type specific patterns of gene activities during
development, cellular reprogramming or pathologica
gene deregulation events in cancer cells, it is
necessary not only to decode the chromatin langua
but also to decipher common rules and cell type-
specific peculiarities of the nuclear architecture at-
large in normal and pathological cell types. Such
studies have been strongly facilitated by recent
methodological breakthroughs. These include geno
wide analyses of DNA-DNA and DNA-protein
interactions in cell populations, as well as advanced
light and electron microscopic studies of single cells
complex tissues. Evidence for aberrant features of
higher order chromatin arrangements in tumor cell
nuclei and cell nuclei from patients with laminopathi
point to a broad, yet still little explored clinical impa
It is important to note in this context that chromoso
instability is a hallmark of cancer cells, but also
common during early mammalian embryogenesis.
Evidence that chromatin arrangements change durin
preimplantation development of mammals underline
the importance of major efforts to generate
quantitative 4D (space and time) maps of nuclei in
normal and pathological cell types. These efforts ar
indispensable to understand the role of nuclear
architecture for normal and pathological gene
expression patterns and other nuclear functions.
8:00
AM
Chromosome territories and the
interchromatin space: Topography of transcriptio
DNA replication and repair.
T. Cremer. LMU
Biocenter, Martinsried, Germany.
8:30
AM
The genome in three dimensions.
J.
Dekker. Grad. Sch. of Biomed. Sci., Univ. of
Massachussetts, USA.
9:00
AM
Nuclear lamina - genome interactions.
van Steensel. Netherlands Cancer Inst., Amsterdam,
Netherlands.
9:30
AM
Role of lamins in normal and
pathological nuclear architecture.
S. A. Adam.
Feinberg Sch. of Med., Northwestern Univ., USA.