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Friday, October 14
Concurrent Invited Session III (45-50)
SESSION 45 – Functional Noncoding RNAs in
Mammalian Systems and Disease
Room 517BC, Level 5, Convention Center
Ahmad M. Khalil, Case Western Reserve
Univ. Sch. of Med., USA; Leonard Lipovich, Wayne
State Univ. Sch. of Med., USA
Recent advances in RNA sequencing technologies
have allowed us to comprehensively examine the RNA
populations present in cells of diverse organisms.
These studies and previous results demonstrate that a
significant proportion of the mammalian genome is
transcribed. While only 1-2% of these transcripts have
the capacity to code for proteins, the majority of RNA
molecules in the endogenous transcriptional output
have no protein coding capacity (non-coding RNAs)
and are thought to function as RNA molecules. In this
session, along with coverage of microRNA and other
short-RNA functions, the focus will be on long non-
coding (lnc)RNAs, which are mRNA-like but lack open
reading frames. lncRNAs range in size from 200
nucleotides to over 10 kb. Many are capped,
polyadenylated, spliced and in some cases conserved.
Very recently, several studies demonstrated that some
lncRNAs are functional, as regulators of chromatin,
nuclear organization, and cell identity. Most intriguingly,
a growing number of mammalian lncRNAs have been
found to function as direct co-regulators of
transcription factors. However, aside from these
examples and a very few well-characterized systems
such as telomerase and X-inactivation, lncRNA
function remains poorly understood. We have selected
key experts in the field of non-coding RNAs (ncRNAs)
who have pioneered the functional analysis of short
and long ncRNAs and have already derived substantial
insights into their biological roles. These investigators
are advancing genome-scale research on the function
of these still-mysterious RNA molecules. Each speaker
will discuss first-hand latest research on ncRNA
functions and mechanisms. The complementary
research areas of the speakers include neuronal
lncRNAs, ncRNA regulation in development and
disease, and studies of lncRNA functions.
A. M. Khalil. Case Western
Reserve Univ. Sch. of Med., USA.
Nuclear-retained noncoding RNAs.
D. L.
Spector. Cold Spring Harbor Lab., NY, USA.
Antisense noncoding RNAs in human
neurological disorders.
C. Wahlestedt. The Scripps
Res. Inst., Jupiter, FL, USA.
Endogenous siRNAs and noncoding
RNA-derived small RNAs are expressed in adult
mouse hippocampus and are upregulated in
olfactory discrimination training.
N. R. Smalheiser.
Univ. of Illinois at Chicago, USA.
Cameras and all other recording devices are
strictly prohibited
in all session rooms. Thank you for your cooperation
Modulating gene expression by targeti
noncoding RNAs.
D. Corey. Univ. of Texas
Southwestern Med. Ctr. at Dallas, USA.
L. Lipovich. Wayne State Univ
Sch. of Med., USA.