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Thursday, October 13
10:15
AM
–12:15
PM
Concurrent Platform Session B (30-39)
SESSION 36 – Cancer Genetics I: Melanoma and
Leukemia
Room 516, Level 5, Convention Center
Moderators:
Florence Demenais, INSERM, France;
David Goldgar, Univ. of Utah, USA
131
/10:15
Two novel loci for melanoma
susceptibility on chromosome bands 1q42.12 and
1q21.3.
S. Macgregor, M. Law, G. W. Montgomery, D.
T. Bishop, C. I. Amos, Q. Wei, K. M. Brown, N. G.
Martin, G. J. Mann, N. K. Hayward.
132
/10:30
Pathway analysis of malignant melanoma
identifies 30 pathways associated with melanoma
cancer risk.
C. E. Amos, L. Wang, W. V. Chen, S.
Fang, J. E. Lee, Q. Wei.
133
/10:45
Genome sequencing of melanoma
families identifies a novel recurrent mutation in
MITF
predisposing to familial and sporadic
melanoma.
K. M. Brown, S. Yokoyama, S.
MacGregor, A. E. Cust, J. Taylor, P. D. Pharoah, D. F.
Easton, A. M. Dunning, J. A. Newton-Bishop, G. W.
Montgomery, N. G. Martin, G. J. Mann, D. T. Bishop,
H. Tsao, J. M. Trent, D. E. Fisher, N. K. Hayward.
134
/11:00
An oncogenic
MITF
germline substitution
p.E318K impairs sumoylation and predisposes to
melanoma and renal carcinoma.
B. Bressac- de
Paillerets, F. Lesueur, S. Giuliano, M. de Lichy, K. Bille,
B. d’Hayer, H. Mohamdi, A. Remenieras, E. Maubec, P.
Vabres, L. Thomas, D. Zelenika, P. Galan, V. Chaudru,
S. Richard, G. Lenoir, M. Lathrop, M.-F. Avril, F.
Demenais, R. Ballotti, C. Bertolotto, French Familial
Melanoma Study Group.
135
/11:15
Melanoma exome sequencing identifies
MEK1/2
as additional driver genes and potential
predisposing variants in genes of DNA repair
pathways.
S. Nikolaev, D. Rimoldi, C. Iseli, A. Valsesia,
C. Gehrig, K. Harshman, M. Guipponi, O. Bukach, V.
Zoete, O. Michielin, K. Muehlethaler, D. Speiser, D.
Robyr, J. S. Beckmann, I. Xenarios, T. D. Halazonetis,
C. V. Jongeneel, B. J. Stevenson, S. E. Antonarakis.
136
/11:30
Genome-wide association study of
melanoma progression and blood biomarkers.
S.
Fang, L. Wang, J. Gershenwald, W. Chen, S. Vattathil,
C. Schacherer, J. Gardner, Y. Wang, T. Bishop, J.
Barrett, E. Grimm, C. McHugh, C. Laurie, K. Doheny,
E. Pugh, Q. Wei, C. Amos, J. Lee.
137
/11:45
Discovery of novel recurrent mutations in
childhood early T-cell precursor acute
lymphoblastic leukemia by whole genome
sequencing.
J. Zhang, L. Ding, L. Holmfeldt, G. Wu,
S. L. Heatley, D. Payne-Turner, J. Easton, X. Chen, J.
Wang, M. Rusch, C. Lu, J. R. Collins-Underwood, J.
Ma, S. B. Pounds, M. Kleppe, J. Cools, M. L.
Hermiston, K. A. Shimano, G. Basso, S. P. Hunger, M.
L. Loh, B. Wood, S. Winter, K. P. Dunsmore, R. S.
Fulton, L. Fulton, C.-H. Pui, R. K. Wilson, J. R.
Downing, C. G. Mullighan, St Jude Children’s
Research Hospital - Washington University Pediatric
Cancer Genome Project.
Cameras and all other recording devices are
strictly prohibited
in all session rooms. Thank you for your cooperati
138
/12:00
GATA2
is a new predisposition gene fo
familial myelodysplastic syndrome and acute
myeloid leukemia.
H. S. Scott, C. N. Hahn, C. E.
Chong, C. L. Carmichael, E. J. Wilkins, P. J. Brautig
X. C. Li, M. Stankovic, M. Lin, A. Carmagnac, Y. K.
Lee, C. H. Kok, L. Gagliardi, K. L. Friend, P. G. Ekert
C. M. Butcher, A. L. Brown, I. D. Lewis, L. B. To, A.
Timms, J. Storek, S. Moore, M. Altree, R. Escher, P.
Bardy, G. K. Suthers, R. J. D’Andrea, M. S. Horwitz.