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Wednesday, October 12
10:30
AM
–12:30
PM
Concurrent Invited Session I (4-9)
(SESSION 8, continued)
12:00
PM
Animal models of OI: Substrates for the
measure and development of therapies and
mechanisms of disease.
B. Lee. Baylor Col. of Med.,
USA.
12:20
PM
Questions and answers.
D. Krakow.
UCLA, USA.
Cameras and all other recording devices are
strictly prohibited
in all session rooms. Thank you for your cooperation
Wednesday, October 12
10:30
AM
–12:30
PM
Concurrent Invited Session I (4-9)
SESSION 9 – Genetic Instability in Development, Agi
and Cancer
Room 517D, Level 5, Convention Center
Moderator:
M. Stephen Meyn, Hosp. for Sick Childr
Toronto, Canada
The past five years have seen rapid progress in our
understanding of the molecular details of our cellula
defenses against genetic instability. At the same tim
there is a growing body of evidence that these
pathways not only protect against cancer, but facilit
normal development and prevent aging. In parallel
these new insights into the biology of genome stabil
pathways, our knowledge of the clinical significance
mutations and polymorphisms in the human genom
stability genes has expanded beyond xeroderma
pigmentosum, ataxia telangiectasia, dyskeratosis
congenita and other classic Mendelian syndromes,
with the recognition of the role played by genome
stability gene variants and inter-individual variation i
DNA repair capacity in cancer and other human
diseases. The four presentations in this session will
survey recent developments in this rapidly moving fi
by: summarizing the roles that DNA break response
genes play both in development and in degeneratio
of the nervous system; reviewing our current
understanding of how nucleotide excision repair
deficiencies affect growth, cancer susceptibility and
aging; describing the critical role played by telomere
maintenance in preventing anemia, myeloid dysplasi
and leukemia; and critically analyzing recent finding
regarding the role of rare genetic variants of DNA
damage response genes in common cancer.
10:30
AM
Introduction.
M. S. Meyn. Hosp. for Sick
Children, Toronto, Canada.
10:45
AM
The role of DNA repair in neurologic
development and disease.
P. McKinnon. St Jude
Children’s Res. Hosp., USA.
11:11
AM
The DNA damage theory of aging —
Evidence from nucleotide excision repair mutant
J. Hoeijmakers. Erasmus Univ. Med. Ctr., Netherland
11:37
AM
Telomere instability and human diseas
P. Lansdorp. Terry Fox Lab., BC Cancer Agcy.,
Vancouver, Canada.
12:03
PM
The role of rare DNA repair gene varia
in human cancer.
S. Tavtigian. Univ. of Utah, USA.