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Wednesday, October 12
Concurrent Invited Session I (4-9)
SESSION 4 – Deciphering Transgenerational Effects:
From Molecular to Statistical Approaches
Room 517BC, Level 5, Convention Center
Janet S. Sinsheimer, David Geffen Sch. of
Med. at UCLA, USA; Amanda E. Toland, The Ohio
State Univ., USA
Despite GWAS success in finding genes associated
with complex diseases and traits, the genetic
architecture of these traits remains mainly unexplained.
Possible explanations include transgenerational
genetic and epigenetic effects. Transgenerational
effects are implicated in infertility as well as in
childhood and adult disorders as diverse as
gestational diabetes mellitus, birth defects, and
schizophrenia. However, approaches to understanding
and detecting these effects are in their infancy. For
example, the genetic studies of infertility are hampered
by difficulties in applying standard genetic approaches
to find the causative mutation. Hence, the genetic
causes of most cases of human infertility remain
elusive. Meanwhile, with the increased use of assisted
reproduction, the transgenerational effects of human
infertility need to be understood. In genetic
epidemiology, detecting transgenerational effects
raises difficult statistical challenges. Detection of joint
maternal-fetal genetic effects requires development of
cost-effective research designs and powerful but
flexible statistical methods. This session presents an
overview that spans molecular approaches to
understanding transgenerational effects to statistical
methods to detect them. Dr. Toland will begin with an
overview of biological concepts that underpin
transgenerational effects. The speakers will next focus
on the genetic basis of core mechanisms as meiosis,
recombination and epigenetic reprogramming during
meiosis and the genetic basis of human infertility and
ways it may affect the next generation’s health. Dr.
Sinsheimer will provide an epidemiological overview.
The speakers will then examine epidemiological
evidence for transgenerational effects in humans such
as imprinting and maternal-fetal genotype
incompatibility and statistical genetic approaches to
detect these effects.
A. E. Toland. The Ohio State
Univ., USA.
The function of genome-wide meiosis-
specific epigenetic marks in recombination.
R. D.
Camerini-Otero. NIDDK/NIH, USA.
Epigenetic consequences of
chromosomal translocations.
A. K. Naumova. McGill
Univ., Canada.
Epidemiological overview.
J. S.
Sinsheimer. David Geffen Sch. of Med. at UCLA, USA.
Cameras and all other recording devices are
strictly prohibited
in all session rooms. Thank you for your cooperati
Intergenerational effects as risk factor
for schizophrenia: The case of maternal-fetal
genotype incompatibility.
C. G. Palmer. David Geff
Sch. of Med. at UCLA, USA.
Detecting complex genetic and
environmental effects with case-control mother-
child pair data.
J. Chen. Univ. of Pennsylvania Sch.
Med., USA.
Investigation of maternal effects,
maternal-fetal interactions and parent-of-origin
effects (imprinting), using mothers and their
H. Cordell. Newcastle Univ., U.K.
A. E. Toland. The Ohio State
Univ., USA.